The South African needed six hours and 36 minutes to see off Isner 7-6 (8-6) 6-7 (5-7) 6-7 (9-11) 6-4 26-24 in a truly epic encounter featuring 102 aces and 96 service games.
But Isner was playing his first Grand Slam semifinal while the South African was in his second after making the US Open final.
Prior to facing the veteran American, Anderson had defeated the heavy favorite and defending champion Roger Federer. Nadal is the most recent major victor, having taken home his 11th title at the French Open last month.
For tournaments without a final set tiebreaker, put John Isner on Centre Court at your own peril.
"It's hard to pick the words".
"Whenever I go out there, I just try to win my match".
"Nothing to complain. I think I played a great match".
"It's very special. It really could have gone either way". It was quite clear that there was very little to separate us, just small details.
But he found himself in even more unfamiliar territory with an inspired Anderson's relentless, thudding serve eventually overpowering the 20-time grand slam victor.
"I had my chances so it's disappointing, but he was consistent and solid".
"You live for these matches". Djokovic is playing at such a high level and is back at the superstar form that won him 12 Grand Slam titles.
Saturday's matchup is a rematch of the 2016 Wimbledon final, when Williams beat Kerber.
"He had a day off which means a lot".
"I don't know what to say right now. That's an incredible achievement".
In a match, which was stopped on Friday night, Djokovic leading two sets to one, due to the 23h00 time curfew after the Anderson v John Isner semi-final took over six hour to complete.
Play in their 52nd career meeting resumed under the roof on Saturday despite bright blue skies and temperatures pushing 30 degrees.
"I think after each win throughout these 10 days, I've had a Kit Kat. I really hope we can look at this, because at the end you don´t feel great", said Anderson who has been on court for over 21 hours at these championships.
David Adair: When the Anderson v Isner match went past 25 games fifth set - you thought history and experience in marathon's made Isner favourite for the first time in the match.
Quotable: "We always played in important stages, important places", Nadal said of facing Djokovic.
In Friday's opening set, Djokovic's serve proved crucial after not faced any break points and earning the crucial break on Nadal's serve in the seventh game with a forehand victor to claim the set 6-4. Fortunately, he was at the end of the court farthest from the Royal Box, where the pair of visiting Duchesses, Kate and the newly married Meghan, sat in the front row.
It said that Butina had broken United States law by not disclosing that she was acting on behalf of the Russian government. Butina has previously said her outreach to American political operatives was purely out of a shared passion for firearms.
And while US spending in constant dollar terms has risen slightly since 2014, its share of NATO's overall spending has fallen. Trump tweeted on Tuesday that the U.S.is paying much more than its allies, which he said is not fair to American taxpayers.
Djokovic saved three set points before taking the third-set tiebreaker to establish a 6-4, 3-6, 7-6 (9) lead. If you watched the video, Serena's quote was a little different than what the @ Wimbledon tweet reads.
She won the grass-court tournament the last two times she played it, in 2015 and 2016, before missing it past year while pregnant. Williams' pregnancy was not without complications, as she told the BBC this week : "It's no secret I had a super tough delivery".
"It's hard to put into words how important Tony Parker has been to the Spurs franchise over the past two decades", he said . Parker will have a piece of his time in San Antonio with him as he sets up camp in Charlotte.
The two drama series picked up 13 and 12 nods respectively, and both were recognized in the coveted top drama category. Saturday Night Live's longest now employed actor garnered his first Emmy nomination since joining the series in 2003.
The world number one was preparing for his Wimbledon second round match against Kazakhstan's Mikhail Kukushkin on Centre Court . Guido Pella of Argentina took out last year's beaten finalist Marin Cilic of Croatia in the second round at Wimbledon.
This is the highest % of team's total scored by any player in a completed innings in all worldwide cricket (Men/Women). Finch is the 2nd player after Chris Gayle to hit 10+ sixes in a T20I innings on two different instances.
Holden, who is a model and a former pro soccer player, told the Today Show Friday what he thinks about the woman he sat next to. As the pair got more serious, so did Rosey. "She's a very very very lovely girl".
Despite a 75 in round two, Korda was still able to climb the leaderboard on Sunday with a 68 for her fifth top 10 of the year. Angel Yin made seven birdies on Sunday and shot just 1-under and tied for fourth, her best finish in a major championship.
The national team, for whom he won 103 caps and also the European Championship as a player, came calling in 2012. Although France were crowned world champions, Giroud has flattered to deceive on a personal level.
Local officials say the attacker detonated a bomb inside a crowded compound where the campaign rally was being held. He has accused Pakistan's powerful security establishment of conspiring against him ahead of the elections.
The princess Charlotte , who has a surprising point in common with the princes George and Louis, and it continues to be noticed. She kept her eye on the press pack as she and the rest of the family headed off for a private afternoon tea at Clarence House.
Expert divers from the Thai Navy SEALs, experienced in conventional diving situations, were faced with an unprecedented challenge. John Volanthen, one of the two British divers who found the boys, played down the gallantry.
In a radio interview with WHAS in Louisville on Friday, Schnatter said he was "just talking the way that the Colonel talked". For the first three months of this year, Papa John's said a key sales figure fell 5.3 percent in North America.
Dictionary.com also pointed out that the searches for "self-made" were up by 18,628 per cent on their website. Kylie Jenner is well on her way to becoming the "youngest self-made United States billionaire".
Kellogg's Honey Smacks cereal has now been linked to at least 100 cases of salmonella infection across the USA since March. At least 30 of the 100 have been hospitalised, while no deaths have been reported, the CDC said .
The Three Lions were kicked out of the tournament last night after a heart-breaking defeat during extra time against Croatia . Prince William, the president of the Football Association, said England could be proud of Southgate's team.
Still, Ice Universe's claim runs directly opposite the increasing number of reports surrounding Samsung's upcoming launch plans. We do not have anything better to offer and companies rarely use logic when naming various phone models so it may well happen.
But by introducing Bluetooth features, Samsung has the potential to make it a phenomenal addition to the Galaxy Note line. We already know the Note 9 will be announced on 9 August in NY (we've collected all the rumours on that over here).